Ruler arrays detect genomic insertions and deletions

A Ruler Array measures the distance between a set of microarray probes and a set of experimentally defined locations in a nucleic acid, offering new possibilities for locating and characterizing changes in the nucleic acid sequence. Despite the known relevance of genomic changes to pathogens, cancer, development, and evolution, many of these changes evade detection by existing high-throughput techniques. Since a microarray can interrogate thousands or millions of probes at once, Ruler Arrays can screen a small genome or part of a mammalian sized genome for insertions, deletions, and inversions in a single experiment.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2009

Author dc:creator

• Rolfe, P. Alexander (Philip Alexander), 1979-

Advisor dc:contributor.advisor

• David K. Gifford.

• Electrical Engineering and Computer Science.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/52803

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/52803