The Mars Gravity Biosatellite as an innovative partial gravity research platform

The Mars Gravity Biosatellite is an unprecedented independent spaceflight platform for gravitational biology research. With a projected first launch after 2010, the low Earth orbit satellite will support a cohort of fifteen 14.5- to 25.5-week-old female BALB/cByJ mice for up to five weeks. During this time, the spacecraft will rotate at a rate of 31.6 rpm to generate Mars-equivalent artificial gravity of magnitude 0.38-g. Reentry capability will permit the return of live specimens to the Earth's surface at the culmination of the study. The proposed first mission aims to explore the physiological impacts on mice of 0.38-g. On board the Mars Gravity Biosatellite, a video acquisition and digitisation system will enhance in-flight collection of data on sensorimotor adaptation. As part of this thesis, a rotational ground control system has been designed and constructed at MIT. The apparatus incorporates a video processing module similar to that baselined for the mission. It also features the first custom-designed gondola centrifuge that accommodates up to four singlyhoused rodents in flight-equivalent habitat modules. At a rotation rate of 31.6 rpm, the centripetal acceleration experienced by each animal is less than 1.07-g. The 0.34 m radius of rotation is equivalent to that of the orbital vehicle. A behavioural study with four BALB/cByJ mice explores the effects of chronic rotation alone and confirms that they can be quantified and therefore decoupled from the anticipated on-orbit effects of rotation-induced Mars-equivalent gravity. The results provide justification for the scientific validity of the Mars Gravity Biosatellite as a rotating spaceflight platform. In addition, details are presented on the design, implementation, test and operation of a two-mouse closed-loop environmental control and life support system (ECLSS). The ground-based assembly is colocated with the centrifuge, and the entire apparatus is enclosed within a sealed zero-pressure urethane/polyethylene membrane. It incorporates scaled-down versions of a subset of flight-equivalent atmospheric reconditioning subassemblies together with sensors, actuators and a computer to perform autonomous feedback-driven supervisory control.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Aeronautics and Astronautics.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2008

Author dc:creator

• Fulford-Jones, Thaddeus R. F

Advisor dc:contributor.advisor

• Jeffrey A. Hoffman.

• Aeronautics and Astronautics.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/46514

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/46514