A system identification approach to non-invasive central cardiovascular monitoring

This thesis presents a new system identification approach to non-invasive central cardiovascular monitoring problem. For this objective, this thesis will develop and analyze blind system identification and input signal reconstruction algorithms for a class of 2-channel IIR and Wiener systems. In particular, this thesis will present blind identifiability conditions for a class of 2-channel IIR and Wiener wave propagation systems and develop the associated blind identification algorithms. It will be shown that the blind identifiability conditions can be achieved in many real-world applications by appropriate selection of channel lengths, sensor locations, and sampling frequency which are the specifications that the system design can exploit for blind identifiability In addition, this thesis will develop a novel input signal reconstruction algorithm that is applicable to general class of multi-channel IIR and Wiener systems. Furthermore, this thesis will rigorously analyze and evaluate three analytic measures for determining the system order and other key parameters of the black-box dynamics as well as for quantifying the quality of the identified gray-box dynamics, without any direct use of unknown input signal: persistent excitation, model identifiability and asymptotic variance. The blind identification and input signal reconstruction algorithms will first be applied to 2-sensor central cardiovascular monitoring problem using two distinct peripheral blood pressure measurements, where the cardiovascular wave propagation dynamics is blindly identified and the aortic blood pressure and flow signals are reconstructed by exploiting black-box and physics-based gray-box model structures of the cardiovascular system.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2008

Author dc:creator

• Hahn, Jin-Oh, Ph. D. Massachusetts Institute of Technology

Advisor dc:contributor.advisor

• H. Harry Asada.

• Mechanical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/45337

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/45337