{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/43815"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/43815","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Intramolecular [4 + 2] cycloadditions of conjugated enynes with highly strained cyclic alkenes","abstract":"Seven- and eight-membered carbocycles are key features in numerous naturally occurring organic substances, many of which are biologically important natural products. This thesis describes studies directed towards the development of a [4 + 3] annulation strategy for the synthesis of seven-membered carbocycles involving the intramolecular [4 + 2] cycloadditions of conjugated enynes with cyclopropenes. 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