{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/42137"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/42137","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Investigation of long-term cyclic loading effects on initially intact cartilage","abstract":"Cartilage, particularly its collagen network, has been suggested by many to be fatigue prone, but the mechanism via which fatigue damage occurs is not yet well-understood. This work seeks to provide a simple framework to further our understanding of the degeneration of this tissue a result of fatigue damage via experimentation and analytical modeling. It was as observed that subjecting initially intact bovine tibial plateau cartilage to repeated long-term applications of an indentation loading protocol, which does not induce any observable damage over a single short-term application, can result in surface damage. The damage can be associated with an increase in the GAG release and decrease in the tissue nominal equilibrium modulus. The ability of the tissue to regain its original configuration also deteriorated with increasing number of loading cycles, but the change was generally gradual. Changes in the optimized parameters obtained from fitting a 1-D rheological model to both the relaxation and cyclic loading responses of cartilage in the undamaged and damaged states suggested that both GAG and collagen have been weakened as a result of damage. A portfolio of data describing the 3-D mechanical behavior of calf tibial plateau cartilage was obtained in this work. It was found that both the axial and lateral responses of cartilage were nonlinear during stress relaxation. Also, the resistance of the tissue to shear and volumetric deformation is dissipative, with the same time constants.","abstract_html":"Cartilage, particularly its collagen network, has been suggested by many to be fatigue prone, but the mechanism via which fatigue damage occurs is not yet well-understood. This work seeks to provide a simple framework to further our understanding of the degeneration of this tissue a result of fatigue damage via experimentation and analytical modeling. It was as observed that subjecting initially intact bovine tibial plateau cartilage to repeated long-term applications of an indentation loading protocol, which does not induce any observable damage over a single short-term application, can result in surface damage. The damage can be associated with an increase in the GAG release and decrease in the tissue nominal equilibrium modulus. The ability of the tissue to regain its original configuration also deteriorated with increasing number of loading cycles, but the change was generally gradual. Changes in the optimized parameters obtained from fitting a 1-D rheological model to both the relaxation and cyclic loading responses of cartilage in the undamaged and damaged states suggested that both GAG and collagen have been weakened as a result of damage. A portfolio of data describing the 3-D mechanical behavior of calf tibial plateau cartilage was obtained in this work. It was found that both the axial and lateral responses of cartilage were nonlinear during stress relaxation. Also, the resistance of the tissue to shear and volumetric deformation is dissipative, with the same time constants.","abstract_has_math":false,"creators":["Wu, Bruce Y. C., 1980-"],"institution":"Massachusetts Institute of Technology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Massachusetts Institute of Technology. Dept. of Materials Science and Engineering.","school":null,"contributors":[],"advisors":["Martha L. Gray and Simona Socrate."],"committee_chairs":[],"committee_members":[],"year":2007,"date_issued":"2007","date_published":"2007","updated_at":"2026-07-22T22:21:27Z","subjects":["Materials Science and Engineering."],"languages":["eng"],"rights":["M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 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They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission."]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://dspace.mit.edu/handle/1721.1/7582"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1721.1/42137"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007.","Includes bibliographical references (leaves 161-170)."]},{"key":"dc:description.abstract","label":"Abstract","values":["Cartilage, particularly its collagen network, has been suggested by many to be fatigue prone, but the mechanism via which fatigue damage occurs is not yet well-understood. This work seeks to provide a simple framework to further our understanding of the degeneration of this tissue a result of fatigue damage via experimentation and analytical modeling. It was as observed that subjecting initially intact bovine tibial plateau cartilage to repeated long-term applications of an indentation loading protocol, which does not induce any observable damage over a single short-term application, can result in surface damage. The damage can be associated with an increase in the GAG release and decrease in the tissue nominal equilibrium modulus. The ability of the tissue to regain its original configuration also deteriorated with increasing number of loading cycles, but the change was generally gradual. Changes in the optimized parameters obtained from fitting a 1-D rheological model to both the relaxation and cyclic loading responses of cartilage in the undamaged and damaged states suggested that both GAG and collagen have been weakened as a result of damage. A portfolio of data describing the 3-D mechanical behavior of calf tibial plateau cartilage was obtained in this work. It was found that both the axial and lateral responses of cartilage were nonlinear during stress relaxation. Also, the resistance of the tissue to shear and volumetric deformation is dissipative, with the same time constants.","(cont.) Finally, differences in the extra- and sub-meniscal tissue were noted. A structurally-based constitutive model that was originally formulated for cervical stroma was employed in this work in attempt to capture the mechanical response of cartilage. It was found able to capture the axial and lateral responses of cartilage in unconfined compression at 20% nominal strain. Changes in the material parameters obtained from fitting the constitutive model to the indentation responses of cartilage in the native and damaged states suggested that damage has induced alterations in both GAG and collagen, echoing our earlier findings."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Ph.D."]},{"key":"dc:title","label":"Title","values":["Investigation of long-term cyclic loading effects on initially intact cartilage"]}]}],"canonical_facts":{"dc:contributor.advisor":["Martha L. Gray and Simona Socrate."],"dc:contributor.department":["Massachusetts Institute of Technology. Dept. of Materials Science and Engineering."],"dc:contributor.other":["Massachusetts Institute of Technology. Dept. of Materials Science and Engineering."],"dc:creator":["Wu, Bruce Y. C., 1980-"],"dc:date.accessioned":["2008-09-03T14:41:51Z"],"dc:date.available":["2008-09-03T14:41:51Z"],"dc:date.issued":["2007"],"dc:description":["Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007.","Includes bibliographical references (leaves 161-170)."],"dc:description.abstract":["Cartilage, particularly its collagen network, has been suggested by many to be fatigue prone, but the mechanism via which fatigue damage occurs is not yet well-understood. This work seeks to provide a simple framework to further our understanding of the degeneration of this tissue a result of fatigue damage via experimentation and analytical modeling. It was as observed that subjecting initially intact bovine tibial plateau cartilage to repeated long-term applications of an indentation loading protocol, which does not induce any observable damage over a single short-term application, can result in surface damage. The damage can be associated with an increase in the GAG release and decrease in the tissue nominal equilibrium modulus. The ability of the tissue to regain its original configuration also deteriorated with increasing number of loading cycles, but the change was generally gradual. Changes in the optimized parameters obtained from fitting a 1-D rheological model to both the relaxation and cyclic loading responses of cartilage in the undamaged and damaged states suggested that both GAG and collagen have been weakened as a result of damage. A portfolio of data describing the 3-D mechanical behavior of calf tibial plateau cartilage was obtained in this work. It was found that both the axial and lateral responses of cartilage were nonlinear during stress relaxation. Also, the resistance of the tissue to shear and volumetric deformation is dissipative, with the same time constants.","(cont.) Finally, differences in the extra- and sub-meniscal tissue were noted. A structurally-based constitutive model that was originally formulated for cervical stroma was employed in this work in attempt to capture the mechanical response of cartilage. It was found able to capture the axial and lateral responses of cartilage in unconfined compression at 20% nominal strain. Changes in the material parameters obtained from fitting the constitutive model to the indentation responses of cartilage in the native and damaged states suggested that damage has induced alterations in both GAG and collagen, echoing our earlier findings."],"dc:description.degree":["Ph.D."],"dc:identifier.uri":["http://hdl.handle.net/1721.1/42137"],"dc:language.iso":["eng"],"dc:publisher":["Massachusetts Institute of Technology"],"dc:rights":["M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission."],"dc:rights.uri":["http://dspace.mit.edu/handle/1721.1/7582"],"dc:subject":["Materials Science and Engineering."],"dc:title":["Investigation of long-term cyclic loading effects on initially intact cartilage"],"dc:type":["Thesis"]},"updated_at":"2026-07-22T22:21:27Z"}