Development and application of a 4-dimensional Computed Tomography simulator

This thesis presents the development and application of a 4-Dimensional Computed Tomography (4D CT) simulation program. The simulation is used to understand and quantify the sources of image artifacts that arise from irregular patient breathing during 4D CT. Performance of the simulation is validated by comparing the simulation results with those of phantom experiments with CT scanners. The program simulates 4D CT scanning of objects of arbitrary size and shape and is extended to investigate the accuracy of gated radiotherapy. Experiments are performed using realistic breathing patterns from patients, in addition to synthetic ones for various studies. The simulation is used to study the effects of scan start time shift, breathing trace baseline drift, and hysteresis of internal organ and abdominal surface motion on the quality of 4D CT images. While 4D CT significantly reduces artifacts from helical scans of the thoracic and abdominal areas, a variety of different sources can still contribute to motioninduced artifacts in 4D CT. Since 4D CT is used to determine target margins for radiotherapy, proper precaution should be taken so that image artifacts do not lead to inaccurate treatment planning. Finally, this thesis discusses improvements in 4D CT and suggests additional methods to improve treatment planning for radiotherapy.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2007

Author dc:creator

• Chu, Alan

Advisor dc:contributor.advisor

• George T.Y. Chen, William M. Wells, Gregory C. Sharp and John A. Wolfgang.

• Electrical Engineering and Computer Science.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/41542

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/41542