The effect of Zoledronate treatment timing on lumbar and caudal vertebrae in ovariectomized rats

Introduction: While there have been numerous studies demonstrating the effect of bisphosphonates in rats as either a preventative treatment or recovering treatment for osteoporosis, few have directly compared the two treatment alternatives with respect to their effects on bone microstructure and strength. This paper, then, investigates the effects of treatment timing using Zoledronate [ZOL], a potent bisphosphonate, on the lumbar and caudal vertebrae in ovariectomized [OVX], female Wistar rats. Methods: Twenty nine rats were divided into four groups according to their treatment: OVX at week 0 (n=5), OVX+earlyZOL (20 jig/kg s.c. week 0, n=8), OVX+late ZOL (20 jlg/kg s.c. week 8, n=7), and SHAM-OVX (n=9). Results: Micro-computed tomography (giCT) evaluation of six parameters characterizing bone morphology [BV/TV, ConnD, SMI, TbTh, TbNr, and TbSp] showed slightly favorable effects with early ZOL treatment in the fourth lumbar [L4] vertebrae. Compared to SHAM-OVX, OVX has a significantly (p<0.05) lower BV/TV, higher SMI, and TbSp. OVX+earlyZOL had a significantly higher BV/TV than OVX and SHAM-OVX and a lower TbSp than OVX.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2007

Author dc:creator

• Ruchelsman, Michal (Michal Aliza)

Advisor dc:contributor.advisor

• Kimberly Hamad-Schifferli.

• Mechanical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/40470

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/40470