The effects of particle size of collagen and mold material on the pore structure of freeze-dried collagen-GAG scaffolds

This study was performed to determine whether the particle size of the starting collagen powder or the material of molds used during freeze-drying had effects on the scaffold pore structure. Collagen particles were separated by size prior to slurry making using a sieve with 1000 [mu]m openings, and scaffolds were made using both metal pans and polysulfone trays, two commonly used molds. The mean and variation of pore diameter and interconnectivity of freeze-dried scaffolds were compared to determine the relationship between particle size or mold material and the resulting pore diameter, for a specific same freeze-drying condition (viz., temperature). Knowing these relationships will permit a better control of pore size during fabrication, allowing researchers to design scaffolds with greater predictability and specificity.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2007

Author dc:creator

• Chan, Jenny K. (Jenny Kamjun)

Advisor dc:contributor.advisor

• Myron Spector.

• Mechanical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/40416

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/40416