Bioelectrical strategies for image-guided therapies

There is a pressing need in minimally-invasive surgery for novel imaging methods that can rapidly and accurately localize the surgical instrument and its target. We have developed two novel localization methods for the guidance of cardiac ablation and other minimally-invasive therapies. The first method, the Inverse Solution Guidance Algorithm (ISGA), is for the non-invasive and rapid localization of the site of origin of an arrhythmia and an ablation catheter tip from body-surface ECG signals. We have substantially developed ISGA to provide accurate catheter guidance even in the presence of significant electrical inhomogeneities, and we have evaluated the method in numerical simulations and phantom studies. Due to the rapidity of arrhythmic origin localization, ISGA may prove a highly effective means of guiding the ablative therapy of hemodynamically-unstable VT. The second method, the Bioelectrical Image Guidance (BIG) Method, is a novel algorithm for the accurate and inexpensive guidance of a wide-range of minimally-invasive surgeries, from cardiac ablation to breast cancer biopsy.

Department dc:contributor.department

Harvard University--MIT Division of Health Sciences and Technology.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2007

Author dc:creator

• Barley, Maya

Advisor dc:contributor.advisor

• Richard J. Cohen.

• Harvard University--MIT Division of Health Sciences and Technology.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/39571
• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Identifier URI

http://dspace.mit.edu/handle/1721.1/39571

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/39571