Surface engineering using layer-by-layer assembly of pH-sensitive polymers and nanoparticles

Surface engineering of a variety of materials including colloidal particles and porous membranes has been achieved by using layer-by-layer assembly of pH-sensitive polymers and nanoparticles. In the first part of this thesis, hydrogen-bonded multilayer coatings comprising poly(acrylic acid) and polyacrylamide were used to functionalize spherical colloidal particles. Multilayer-modified colloids showed an excellent resistance to cell adhesion. Hydrogen-bonded multilayer coatings on microspheres also could be utilized as templates for in situ nanoparticle synthesis enabling the formation of nanoparticle-loaded hollow microcapsules. Silver nanoparticle-loaded multilayer coatings were created on magnetic microspheres to create antibacterial agents that can be manipulated using a magnetic field. In the second part, the surfaces of track-etched polycarbonate membranes were functionalized with multilayer coatings that undergo discontinuous swelling transition. Multilayers comprising poly(allylamine hydrochloride) and poly(styrene sulfonate) were deposited at a high pH condition (pH > 9.0). These multilayer-modified membranes exhibited hysteretic gating behavior that could be useful for the separation of pH-sensitive materials such as proteins.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Chemical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2007

Author dc:creator

• Lee, Daeyeon

Advisor dc:contributor.advisor

• Robert E. Cohen and Michael F. Rubner.

• Chemical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/38979
• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Identifier URI

http://dspace.mit.edu/handle/1721.1/38979

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/38979