Predicting the risk and trajectory of intensive care patients using survival models

Using artificial intelligence to assist physicians in patient care has received sustained interest over the past several decades. Recently, with automated systems at most bedsides, the amount of patient information collected continues to increase, providing specific impetus for intelligent systems that can interpret this information. In fact, the large set of sensors and test results, often measured repeatedly over long periods of time, make it challenging for caregivers to quickly utilize all of the data for optimal patient treatment. This research focuses on predicting the survival of ICU patients throughout their stay. Unlike traditional static mortality models, this survival prediction is explored as an indicator of patient state and trajectory. Using survival analysis techniques and machine learning, models are constructed that predict individual patient survival probabilities at fixed intervals in the future. These models seek to help physicians interpret the large amount of data available in order to provide optimal patient care. We find that the survival predictions from our models are comparable to survival predictions using the SAPS score, but are available throughout the patient's ICU course instead of only at 24 hours after admission. Additionally, we demonstrate effective prediction of patient mortality over fixed windows in the future.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2006

Author dc:creator

• Hug, Caleb W. (Caleb Wayne)

Advisor dc:contributor.advisor

• Peter Szolovits.

• Electrical Engineering and Computer Science.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/38326

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/38326