A Lorentz-force actuated controllable needle-free drug delivery system

The advantages of delivering injections via needle-free methods are numerous. However, conventional methods for needle-free injection lack sufficient control over depth of penetration and shape of injection. Thus, a needle-free injector was designed, constructed, and tested, using a controllable linear Lorentz-force actuator. This actuator allows rapid control of the injection pressure during injections. Using this device, precise control over delivery parameters can be achieved. In addition, several portable power systems for this injector were developed, allowing the energy-intensive needle-free injector to be used in the field. The injector design was tested for repeatability and use for both in-vitro and in-vivo testing on murine tissue using a bacterial collagenase.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2004

Author dc:creator

• Hemond, Brian D. (Brian David Thomson)

Advisor dc:contributor.advisor

• Ian W. Hunter.

• Electrical Engineering and Computer Science.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/37201

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/37201