{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/36737"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/36737","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Thermal-based probe for testing endothelial dysfunction and possible implications for diagnosing atherosclerosis","abstract":"Endothelial dysfunction is a precursor to atherosclerosis. Thus, the vascular health of an individual can be assessed if endothelial dysfunction can be readily and unambiguously quantified. A thermal-based approach using temperature and blood perfusion measurements in conjunction with an arterial challenge has the potential to quantitatively assess endothelial dysfunction. This report includes a detailed review of previous attempts to characterize endothelial dysfunction and a preliminary evaluation of a thermal-based approach that relies on temperature and perfusion measurements. Two simple thermal models are used to contextualize results obtained from this technique. Results reveal that this thermal-based method serves as a valid indicator of endothelial assessment while at the same time reducing some of the mitigating factors of existing approaches to identifying endothelial dysfunction. More testing must be performed in order to optimize this thermal-based approach.","abstract_html":"Endothelial dysfunction is a precursor to atherosclerosis. Thus, the vascular health of an individual can be assessed if endothelial dysfunction can be readily and unambiguously quantified. A thermal-based approach using temperature and blood perfusion measurements in conjunction with an arterial challenge has the potential to quantitatively assess endothelial dysfunction. This report includes a detailed review of previous attempts to characterize endothelial dysfunction and a preliminary evaluation of a thermal-based approach that relies on temperature and perfusion measurements. Two simple thermal models are used to contextualize results obtained from this technique. Results reveal that this thermal-based method serves as a valid indicator of endothelial assessment while at the same time reducing some of the mitigating factors of existing approaches to identifying endothelial dysfunction. More testing must be performed in order to optimize this thermal-based approach.","abstract_has_math":false,"creators":["Lediju, Muyinatu A. (Muyinatu Adebisi)"],"institution":"Massachusetts Institute of Technology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Massachusetts Institute of Technology. Dept. of Mechanical Engineering.","school":null,"contributors":[],"advisors":["H. 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More testing must be performed in order to optimize this thermal-based approach."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["S.B."]},{"key":"dc:title","label":"Title","values":["Thermal-based probe for testing endothelial dysfunction and possible implications for diagnosing atherosclerosis"]}]}],"canonical_facts":{"dc:contributor.advisor":["H. Frederick Bowman."],"dc:contributor.department":["Massachusetts Institute of Technology. Dept. of Mechanical Engineering."],"dc:contributor.other":["Massachusetts Institute of Technology. Dept. of Mechanical Engineering."],"dc:creator":["Lediju, Muyinatu A. 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Two simple thermal models are used to contextualize results obtained from this technique. Results reveal that this thermal-based method serves as a valid indicator of endothelial assessment while at the same time reducing some of the mitigating factors of existing approaches to identifying endothelial dysfunction. More testing must be performed in order to optimize this thermal-based approach."],"dc:description.degree":["S.B."],"dc:identifier.uri":["http://hdl.handle.net/1721.1/36737"],"dc:language.iso":["eng"],"dc:publisher":["Massachusetts Institute of Technology"],"dc:rights":["M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. 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