Enabling sample tracking in and reducing variability in DNA library construction

The Broad Institute is a world leader in genomic sequencing. The Institute gained prominence during the Human Genome Project and has continued to be the nation's leading public laboratory for genomic sequencing projects. The Broad Institute has done this by taking advantage of economies of scale, rapid process innovation, and new process implementation. Strong execution has made The Broad Institute the lowest cost and highest quality sequencing operation in the country. As biological science evolves, The Broad Institute will focus on low-volume, highly targeted areas of a genome rather than high-volume, full genome sequencing projects. In order for the Institute to maintain high-quality output at low cost, it must change its operations strategy from mass production to flexible, lean production. The operations organization has begun the lean production journey by hiring operations focused managers and initiating a Six Sigma program to utilize their employees to innovate and optimize processes. This effort has been supplemented with 5S (systematic organization) and information systems that improve communication between groups.

Department dc:contributor.department

Leaders for Manufacturing Program at MIT

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2006

Author dc:creator

• Penake, David A. (David Allen)

Advisor dc:contributor.advisor

• Roy Welsch and Darrell J. Irvine.

• Materials Science and Engineering.
• Sloan School of Management.
• Leaders for Manufacturing Program.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/36221

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/36221