Microdamage accumulation in bovine trabecular bone

When bone is loaded beyond its failure point, it develops damage in the form of microcracks. Normally, microcracks are repaired by the remodeling process, limiting the number of in vivo microcracks. However, if the rate of microdamage accumulation increases or the rate of remodeling slows, microdamage can accumulate, reducing bone stiffness and strength and may lead to stress fractures or fragility fractures. A new technique for visualizing microdamage in vitro has been developed that uses chelating fluorochromes to label microcracks. Sequential staining is used to distinguish between microdamage that occurred before testing and damage created during testing. Microdamage parameters quantified include the total number of microcracks, total length of microcracks, damaged area, the number of trabeculae containing microcracks, the pattern of microcracking, the extent of microdamage across the thickness of the trabeculae, and the size of the damage-containing region in the specimen. The chelating fluorochrome marker technique was used to label and quantify microdamage in specimens of bovine trabecular bone damaged in uniaxial compression and compressive fatigue, and relationships between microdamage parameters and changes in mechanical properties (maximum compressive strain, modulus reduction) were quantified.

Department dc:contributor.department

Harvard University--MIT Division of Health Sciences and Technology.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2001

Author dc:creator

• Moore, Tara L. Arthur (Tara Lee Arthur), 1972-

Advisor dc:contributor.advisor

• Lorna J. Gibson.

• Harvard University--MIT Division of Health Sciences and Technology.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/36103

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/36103