Design and development of a 3D X-ray microscope

The rapid development of needle-free injection systems demands better and faster imaging systems, capable of imaging the transient and steady state response of an injection into real tissue. X-ray radiography, x-ray microscopy, and computerized tomography (CT) were identified as the most appropriate imaging techniques used for non-invasive imaging of opaque objects and an instrument was constructed, utilizing all of those techniques. The instrument was capable of producing x-ray radiographies with native resolution of less than 30 [mu]m, frame rate of 32 frames per second and a field of view of 30 mm by 40 mm. Using magnifying cone-beam x-ray source the ultimate resolution of the system exceeded 5 [mu]m, while maintaining image sharpness and clarity. Digital image reconstruction techniques, based on the inverse Radon transformation and the Fourier slice theorem were used to regenerate conventional CT images as well as contrast volumetric 3D images of the internal structures of opaque objects. This paper presents the design and development of the 3D x-ray microscope together with experimental results obtained during the calibration and initial testing of the instrument.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2006

Author dc:creator

• Brayanov, Jordan, 1981-

Advisor dc:contributor.advisor

• Ian W. Hunter.

• Mechanical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/35677

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/35677