A spectroscopic system for near infrared glucose measurement

Noninvasive blood glucose monitoring has been long envisioned to serve as an invaluable tool in the treatment of diabetes. The current invasive method makes it difficult for diabetic patients to perform frequent blood glucose measurements and maintain better control of their glucose levels, crucial in reducing the risks of complications. In this thesis, the use of the near infrared absorption spectroscopy is proposed and investigated. The light radiation is envisioned to be transmitted through thin tissue such as the webbing tissue between the thumb and the index finger. The main technical difficulties are identified to be those caused by complex interferences from other physiological variables and the weak near infrared glucose signals. Thus, the success of such a method hinges on adequately isolating the glucose signals from among the interferences as well as on obtaining high signal-to-noise-ratio spectra. The first objective of this thesis is to provide deeper quantitative understanding to the challenges described above. Such knowledge is key to developing clinically accurate and robust devices. This objective is accomplished through a series of systematic experimental and analytical investigations involving glucose measurements in various biological sample matrices.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2004

Author dc:creator

• Saptari, Vidi Alfandi, 1975-

Advisor dc:contributor.advisor

• Kamal Youcef-Toumi.

• Mechanical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/34131

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/34131