Estimation of nonlinear mechanical properties of atherosclerotic plaques

A numerical method has been developed to estimate the mechanical properties of atherosclerotic plaques by combining genetic algorithm with finite element methods. Plaque images derived from optical coherence tomography were employed to construct finite element models which were subsequently used in conjunction with a genetic algorithm to determine the parameters in a nonlinear constitutive model. A new multi-frame scheme is introduced to better perform the estimation on a nonlinear mechanical model and reduce the effects of noise. Results show while it is feasible to estimate the nonlinear mechanical properties of plaque, the accuracy can depend on various factors, especially the noise. KEY woRDS: FEM, atherosclerotic plaques, parameter estimation, Mooney-Rivlin model, optical coherence tomography, image noise.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2005

Author dc:creator

• Zhu, Ting F. (Ting Fredrick)

Advisor dc:contributor.advisor

• Roger D. Kamm and Mohammad R. Kaazempur Mofrad.

• Mechanical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/33907

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/33907