{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/33623"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/33623","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Technical, economic, and clinical challenges to the development of new biomaterials-based vaccines","abstract":"Research into novel vaccine methods is becoming increasingly important for the potential treatment of widespread diseases such as cancer, HIV, and malaria. Members of the Irvine laboratory have developed a hydrogel and particle-based injectable vaccine with the potential to treat such diseases. The vaccine aims to elicit a tailored immune response to a particular type of disease so as to destroy infected or cells in the body and/or develop immunological memory for future protection against the disease. The purpose of this paper is to analyze the feasibility of getting such a biomaterials-based novel vaccination method to the market. Topics such as application potential, efficacy, modes of delivery, storage, patent ability, and costs for producing the vaccine are explored. Finally, a suggested business strategy is outlined, through which value can be successfully obtained from the novel vaccine.","abstract_html":"Research into novel vaccine methods is becoming increasingly important for the potential treatment of widespread diseases such as cancer, HIV, and malaria. Members of the Irvine laboratory have developed a hydrogel and particle-based injectable vaccine with the potential to treat such diseases. The vaccine aims to elicit a tailored immune response to a particular type of disease so as to destroy infected or cells in the body and/or develop immunological memory for future protection against the disease. The purpose of this paper is to analyze the feasibility of getting such a biomaterials-based novel vaccination method to the market. Topics such as application potential, efficacy, modes of delivery, storage, patent ability, and costs for producing the vaccine are explored. Finally, a suggested business strategy is outlined, through which value can be successfully obtained from the novel vaccine.","abstract_has_math":false,"creators":["Huffman, Kathleen Renee"],"institution":"Massachusetts Institute of Technology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":"Massachusetts Institute of Technology. Dept. of Materials Science and Engineering.","school":null,"contributors":[],"advisors":["Darrell J. Irvine."],"committee_chairs":[],"committee_members":[],"year":2005,"date_issued":"2005","date_published":"2005","updated_at":"2026-07-22T22:21:13Z","subjects":["Materials Science and Engineering."],"languages":["eng"],"rights":["M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission."],"rights_urls":["http://dspace.mit.edu/handle/1721.1/7582"],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1721.1/33623","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Darrell J. Irvine."]},{"key":"dc:contributor.department","label":"Department","values":["Massachusetts Institute of Technology. Dept. of Materials Science and Engineering."]},{"key":"dc:contributor.other","label":"Dc Contributor Other","values":["Massachusetts Institute of Technology. Dept. of Materials Science and Engineering."]},{"key":"dc:creator","label":"Author","values":["Huffman, Kathleen Renee"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2006-07-31T15:17:56Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2006-07-31T15:17:56Z"]},{"key":"dc:date.issued","label":"Date","values":["2005"]},{"key":"dc:publisher","label":"Institution","values":["Massachusetts Institute of Technology"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Materials Science and Engineering."]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission."]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://dspace.mit.edu/handle/1721.1/7582"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1721.1/33623"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2005.","Includes bibliographical references (leaves 81-87)."]},{"key":"dc:description.abstract","label":"Abstract","values":["Research into novel vaccine methods is becoming increasingly important for the potential treatment of widespread diseases such as cancer, HIV, and malaria. Members of the Irvine laboratory have developed a hydrogel and particle-based injectable vaccine with the potential to treat such diseases. The vaccine aims to elicit a tailored immune response to a particular type of disease so as to destroy infected or cells in the body and/or develop immunological memory for future protection against the disease. The purpose of this paper is to analyze the feasibility of getting such a biomaterials-based novel vaccination method to the market. Topics such as application potential, efficacy, modes of delivery, storage, patent ability, and costs for producing the vaccine are explored. Finally, a suggested business strategy is outlined, through which value can be successfully obtained from the novel vaccine."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["M.Eng."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Technical, economic, and clinical challenges to the development of new biomaterials-based vaccines"]}]}],"canonical_facts":{"dc:contributor.advisor":["Darrell J. Irvine."],"dc:contributor.department":["Massachusetts Institute of Technology. Dept. of Materials Science and Engineering."],"dc:contributor.other":["Massachusetts Institute of Technology. Dept. of Materials Science and Engineering."],"dc:creator":["Huffman, Kathleen Renee"],"dc:date.accessioned":["2006-07-31T15:17:56Z"],"dc:date.available":["2006-07-31T15:17:56Z"],"dc:date.issued":["2005"],"dc:description":["Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2005.","Includes bibliographical references (leaves 81-87)."],"dc:description.abstract":["Research into novel vaccine methods is becoming increasingly important for the potential treatment of widespread diseases such as cancer, HIV, and malaria. Members of the Irvine laboratory have developed a hydrogel and particle-based injectable vaccine with the potential to treat such diseases. The vaccine aims to elicit a tailored immune response to a particular type of disease so as to destroy infected or cells in the body and/or develop immunological memory for future protection against the disease. The purpose of this paper is to analyze the feasibility of getting such a biomaterials-based novel vaccination method to the market. Topics such as application potential, efficacy, modes of delivery, storage, patent ability, and costs for producing the vaccine are explored. Finally, a suggested business strategy is outlined, through which value can be successfully obtained from the novel vaccine."],"dc:description.degree":["M.Eng."],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["http://hdl.handle.net/1721.1/33623"],"dc:language.iso":["eng"],"dc:publisher":["Massachusetts Institute of Technology"],"dc:rights":["M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission."],"dc:rights.uri":["http://dspace.mit.edu/handle/1721.1/7582"],"dc:subject":["Materials Science and Engineering."],"dc:title":["Technical, economic, and clinical challenges to the development of new biomaterials-based vaccines"],"dc:type":["Thesis"]},"updated_at":"2026-07-22T22:21:13Z"}