Development of bi-layer mineralized bone and cartilage regeneration template

Porous collagen-glycosaminoglycan (CG) scaffolds have been studied extensively and proven to be capable of tissue regeneration in vivo for applications including skin regeneration templates, hollow nerve guides and conjunctiva regeneration. While the current CG scaffold has been thoroughly examined both mechanically and clinically, it has yet to prove appropriate for load- bearing applications. This study will investigate the mechanical properties of a mineralized CG scaffold and its application potential in a load-bearing environment. Through the introduction of calcium-phosphate mineral into the standard CG formulation the matrix analog will be available for bone regeneration. Utilizing a patented triple co-precipitation technique developed at Massachusetts Institute of Technology and Cambridge University, a homogeneous mineralized scaffold will be manufactured. Comparison to healthy trabecular bone as well as the selection of the most appropriate extracellular matrix analog will be presented. The key to commercial success is the introduction of a bi-layer bone and cartilage regeneration template to address concerns and difficulties in cartilage repair today. This dual combination is termed a layered osteochondral scaffold.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Materials Science and Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2005

Author dc:creator

• Ott, Cassandra Holzgartner

Advisor dc:contributor.advisor

• Lorna J. Gibson.

• Materials Science and Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/33620

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/33620