Surgical system for image-based stereotaxy in the rat

Currently there are no of MRI image-based stereotactic apparatus for target determination in the brain of animals. Until now, the only stereotactic devices for directing problems and electrodes in animal brains for neuroscience are based on dental and ear canal fixation and on skull based features which are at best crudely related to brain anatomy. As a result there is no accurate method or apparatus to place a probe into the brain of a research animal. Proposed here is a surgical system to replace these outmoded techniques. The system consists of a MR compatible head frame and a MR localizer designed specifically for the Norway species of rat. This system allows for accurate targeting of structures within the rodent brain and precision placement of electrodes to these structures. This system utilizes the most current MRI imaging technologies available to provide major improvements to quality and reliability in neuroscience data acquisition.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Mechanical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2005

Author dc:creator

• Cosman, Niels Johnson

Advisor dc:contributor.advisor

• Eric R. Cosman.

• Mechanical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/32867

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/32867