Distant hemodynamic impact of local geometric alterations in the arterial tree

Hemodynamics has long been identified as a major factor in the determination and localization of atherosclerotic lesions. While the precise mechanism by which different hemodynamic factors act is not yet clear, the fact that they correlate highly with atherogenesis suggests that local disturbances in flow through blood vessels can promote arterial disease. These issues have become increasingly acute as physicians seek to alter the pathological arterial anatomy with bypass grafting or endovascular manipulations such as angioplasty or stenting. We proposed that local vascular interventions might cause previously unforeseen effects elsewhere in the arterial tree. As an example of these interactions, manipulation of one branch of a bifurcation might adversely affect the contralateral branch of the bifurcation. The goal of this work was to study the distant impact of local flow alterations, as well as to classify and evaluate the different parameters that determine their severity. Dynamic flow models of the arterial system were developed that allowed for the continuous alteration of model geometry in a controlled fashion to simulate the healthy and diseased states as well as the entire range in between. Moreover, these models permit simulation of different strategies of clinical intervention. Flow through the models was investigated using both qualitative and quantitative tools. Boundary layer separation and vascular resistance in one location of the arterial tree varied with geometrical alterations in another. In-vivo models were developed that allowed investigation of the effect of side branch occlusion or dilation on the acute and chronic outcome of main branch stenting in a bifurcation. Chronic side branch occlusions were protective of main branch stenting as reflected by a reduction in in-stent neo-intimal hyperplasia.

Department dc:contributor.department

Harvard University--MIT Division of Health Sciences and Technology.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2003

Author dc:creator

• Richter, Yoram, 1971-

Advisor dc:contributor.advisor

• Elazer R. Edelman.

• Harvard University--MIT Division of Health Sciences and Technology.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/29944

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/29944