Investigation of bone response to implant materials by electron microscopy and computer simulation

(cont.) implementation of this scintigraphic method for quantitative studies of osteoblast-mediated mineralization in vitro. A 2-D truss finite element model is used to study the remodeling of trabecular bone. Using strain energy density (SED) as the optimization object and the trabecular width as the optimization variable, an optimal structure with minimum SED was achieved. This structure is similar to real bone in the dense outside, porous inside, and orientation of the trabeculae. The bone density distribution pattern also matched with previous result by other people. Different implants were introduced to simulate the replacement for the femoral head. It has been proved that the difference in Young's modulus between bone and implant materials is the main reason for the long-term bone loss (stress screening). This problem can be alleviated by proper implant design and resurfacing instead of replacing the whole femoral head.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Materials Science and Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2004

Author dc:creator

• Wang, Hao, 1974-

Advisor dc:contributor.advisor

• Linn W. Hobbs and W. Craig Carter.

• Materials Science and Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/28884

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/28884