Bridging the Gap: From Artificial Intelligence and Optimization Theory to Action

Despite significant theoretical advances in Operations Research (OR) and Artificial Intelligence (AI), a persistent gap remains between these developments and their practical implementation in real-world settings. Despite significant progress in these fields, many OR and ML approaches struggle to scale to realistic problem sizes, lack robustness to uncertainty, or fail to address implementation constraints faced by practitioners in industry. Through four distinct works conducted in collaboration with industry partners, this research demonstrates how methodological advancements can bridge this theory-practice divide while maintaining rigorous theoretical foundations and guarantees. In the first part, we focus on optimization methodologies that scale traditional OR approaches to handle real-world problem sizes and uncertainty. In Chapter 2, we develop a stochastic Benders decomposition scheme for large-scale network design problems, a class of problems ubiquitous in logistics, transportation, and energy sectors. By incorporating sampling techniques within the decomposition framework, we achieve deterministic optimality guarantees while reducing computational costs, enabling solutions for networks with 700 nodes—an order of magnitude larger than previously tractable instances—while achieving optimality gaps of 5-7% compared to 16-27% for traditional deterministic approaches. In Chapter 3, we present a holistic framework for industrial decarbonization, developed with a major phosphate producer planning to quadruple energy consumption while transitioning to renewable sources. Our robust optimization approach combines strategic capacity expansion planning over a 25-year horizon with adaptive operational models, providing 95% reliability guarantees while balancing solar and wind integration with battery storage to meet a projected 12 TWh annual demand. In the second part, we shift our focus to developing AI systems that address the unique challenges of medical data abstraction and clinical decision support. In Chapter 4, we address the challenge of automating clinical data abstraction from electronic health records, collaborating with the Society of Thoracic Surgeons to populate their Adult Cardiac Surgery Database. Our AI pipeline combines 31 models per target variable with a two-tiered quality control system, achieving over 99% accuracy while automatically extracting 43-50% of registry variables, demonstrating how AI can dramatically reduce manual abstraction burden while maintaining clinical standards. In Chapter 5, we extend this healthcare AI focus by developing xHAIM (Explainable Holistic AI in Medicine), which addresses the limitations of current clinical AI systems in handling extensive patient records, providing interpretability, and incorporating medical knowledge. Through semantic similarity techniques and generative AI, xHAIM improves predictive performance while generating clinically grounded explanations that enhance trust and adoption by healthcare practitioners.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Operations Research Center

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2025

Author dc:creator

• Petridis, Periklis S.

Advisor dc:contributor.advisor

• Bertsimas, Dimitris J.

Statement dc:rights

• Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
• Copyright retained by author(s)

Licence dc:rights.uri

• https://creativecommons.org/licenses/by-nc-nd/4.0/

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/164493

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/164493