Development of Multi-Modality Imaging Cart for Barrett’s Esophagus

Barrett’s Esophagus (BE) is a key precursor to esophageal adenocarcinoma (EAC), but current screening and risk assessment methods are ineffective and costly. Many BE cases remain undiagnosed due to asymptomatic patients, and existing risk algorithms rely on patient data rather than biomarkers. This work aims to start building a risk progression model by using a multi-modal imaging system combining autofluorescence spectroscopy, optical coherence tomography, and diffuse reflectance spectroscopy to perform label-free optical biopsies on ex-vivo tissue. These images will be co-registered and validated with histological biomarkers for BE. The ultimate goal is to develop a non-invasive endoscopic capsule and algorithm to better assess BE progression and enhance early detection of EAC.

Name thesis:degree_name

Master

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2025

Author dc:creator

• Qu, Ashley

Advisor dc:contributor.advisor

• Tearney, Guillermo J.

Statement dc:rights

• In Copyright - Educational Use Permitted
• Copyright retained by author(s)

Licence dc:rights.uri

• https://rightsstatements.org/page/InC-EDU/1.0/

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/163726

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/163726