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Massachusetts Institute of Technology
Mapping the Spatial Transcriptome Across Whole Organisms
Abstract
dc:description.abstractThis study utilizes Expansion Sequencing (ExSeq) to thoroughly investigate the spatial transcriptome of the Caenorhabditis elegans (C. elegans) body. Beyond mapping gene distribution within individual specimens, this research sequences multiple C. elegans to identify both shared and distinct transcriptomic features. The findings lay crucial groundwork for future integration of transcriptomic data with in situ connectomics and in vivo neural activity recordings. Understanding the spatial transcriptome in C. elegans is vital for insights into neural circuit coordination, disease mechanisms, and developmental biology.
Degree
thesis:*- Name thesis:degree_name
- Doctoral
- Department dc:contributor.department
- Program in Media Arts and Sciences (Massachusetts Institute of Technology)
- Grantor dc:publisher
- Massachusetts Institute of Technology
- Year dc:date.issued
- 2025
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Zhang, Ruihan
- Advisors dc:contributor.advisor
-
- Jacobson, Joseph M.
- Boyden, Edward S.
Rights
dc:rights- Statement dc:rights
-
- In Copyright - Educational Use Permitted
- Copyright retained by author(s)
- Licence dc:rights.uri
Identifiers
dc:identifier.*- Handle dc:identifier.uri
- https://hdl.handle.net/1721.1/159122
- OAI identifier oai:identifier
- oai:dspace.mit.edu:1721.1/159122