Geo-UNet: A Geometrically Constrained Neural Framework for Clinical-Grade Lumen Segmentation in Intravascular Ultrasound

Precisely estimating lumen boundaries in intravascular ultrasound (IVUS) is needed for sizing interventional stents to treat deep vein thrombosis (DVT). Unfortunately, current segmentation networks like the UNet lack the precision required for clinical adoption in IVUS workflows. This arises due to the difficulty of automatically learning accurate lumen contour from limited training data while accounting for the radial geometry of IVUS imaging. We propose the Geo-UNet framework to address these issues via a design informed by the geometry of the lumen contour segmentation task, building anatomical constraints directly into the architecture. We first convert the input data and segmentation targets from Cartesian to polar coordinates. Starting from a convUNet feature extractor, we propose a two-task setup, one for conventional pixel-wise labeling and the other for single boundary lumen-contour localization. We directly combine the two predictions by passing the predicted lumen contour through a new activation (named CDFeLU) to filter out spurious pixel-wise predictions. Our unified loss function carefully balances area-based, distance-based, and contour-based penalties to provide near clinical-grade generalization in unseen patient data. We also introduce a lightweight, inference-time technique to enhance segmentation smoothness. The efficacy of our framework on a venous IVUS dataset is shown against state-of-the-art models. We will make the code repository for this project available soon after approval from industry collaborators.

Name thesis:degree_name

Master

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2024

Author dc:creator

• Chen, Yiming

Advisor dc:contributor.advisor

• Golland, Polina

Statement dc:rights

• Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
• Copyright retained by author(s)

Licence dc:rights.uri

• https://creativecommons.org/licenses/by-nc-nd/4.0/

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/157219

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/157219