Chemical Sensing as a Utility using Swept-Source Raman Spectroscopy

The integration of chemical sensing into everyday life is a decades-old dream that has so far failed to come to fruition. Many sensor technologies have been proposed and developed, but few can claim to be non-destructive, reagent-free, and suitable for multiple applications while also enabling significant scale-up and remaining cost-effective. This thesis proposes a utility service model for chemical sensing using Swept Source-Raman Spectroscopy (SSRS) that addresses these challenges. First, we introduce the SSRS fiber-probe that allows to measure Raman spectra with a single-point detector and only a few milliwatts of tunable laser excitation. We validate the probe design by monitoring nitrate fertilizer in a hydroponic setup, in environmental water samples, and in growing plants with sensitivity and resolution which are equivalent to benchtop systems. We further demonstrate the scaling up of SSRS into a sensor network by leveraging readily-available data communication optical fiber infrastructure. We showcase a 16-sensor network that uses the laser as a shared resource and develop an engineering-based cost model that supports the scaling up of this network to dozens of sensors deployed over kilometers. Lastly, we monitor metabolites in a therapeutic-producing cell culture, and use linear regression models and a-priori information of our samples to reduce the spectral acquisition time, making this sensor architecture competitive in both performance and cost to existing solutions. These findings represent significant progress towards achieving ubiquitous chemical sensing and facilitating the integration of chemical sensors into everyday life.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2024

Author dc:creator

• Persits, Nili

Advisor dc:contributor.advisor

• Ram, Rajeev J.

Statement dc:rights

• In Copyright - Educational Use Permitted
• Copyright retained by author(s)

Licence dc:rights.uri

• https://rightsstatements.org/page/InC-EDU/1.0/

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/156629

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/156629