Abstract
dc:description.abstractThe research combines two studies in the field of clinical trials. The first evaluates the amyotrophic lateral sclerosis (ALS) drug AMX0035 using Bayesian decision analysis (BDA), balancing FDA safety standards with patient needs. This method provides a quantitative way to consider both the patient’s perspective and the disease’s impact. The second study uses machine learning models to predict how long clinical trials will take. By analyzing a large dataset, it identifies factors that affect trial duration, helping to streamline the trial process and potentially reduce costs. Together, these studies offer new ways to evaluate and manage clinical trials, combining patient-focused evaluation with efficient trial design.
Degree
thesis:*- Name thesis:degree_name
- Master
- Department dc:contributor.department
- Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
- Grantor dc:publisher
- Massachusetts Institute of Technology
- Year dc:date.issued
- 2024
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Cho, Joonhyuk
- Advisor dc:contributor.advisor
-
- Lo, Andrew W.
Rights
dc:rights- Statement dc:rights
-
- In Copyright - Educational Use Permitted
- Copyright retained by author(s)
- Licence dc:rights.uri
Identifiers
dc:identifier.*- Handle dc:identifier.uri
- https://hdl.handle.net/1721.1/153768
- OAI identifier oai:identifier
- oai:dspace.mit.edu:1721.1/153768