T2 Characterization of Oil-In-Water Emulsions for NMR Sensor Applications

Fluid status assessment is an essential aspect of healthcare with implications in chronic conditions such as renal disease and congestive heart failure. Current fluid status determination techniques lack quantitative methods and standards. Our research explores a point-of-care approach through a portable single-sided magnetic resonance (MR) sensor. We are developing a more accurate and clinically relevant hydration metric through measuring localized skeletal muscle. Phantoms are used as stand-ins for a human subject to calibrate and ensure system functionality. The microstructure of an emulsion also mimics the multiple compartments of tissue such as the intra and extracellular volumes of muscle and adipose tissue. We aim to use oil-in-water emulsions as phantoms to ensure device reproducibility and determine how much the scale of the microstructure affects relaxation behavior. A quantitative understanding of the length scales appropriate for muscle and adipose tissue will help determine the reliability of our hydration measurement.

Name thesis:degree_name

Master

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Materials Science and Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2024

Author dc:creator

• Zammit, Alexa S.

Advisor dc:contributor.advisor

• Cima, Michael J.

Statement dc:rights

• In Copyright - Educational Use Permitted
• Copyright retained by author(s)

Licence dc:rights.uri

• https://rightsstatements.org/page/InC-EDU/1.0/

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/153667

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/153667