Abstract
dc:description.abstractInnovation at the level of platforms provides the greatest leverage for shaping science and technology. Here, two key weaknesses in platforms for biology are addressed: the lack of accessible, extensible open-source software for the exploding field of robotic bioautomation, and the lack of a standardized, consistent screening platform for the manufacture of dangerous DNA. Pyhamilton and SecureDNA are introduced. Pyhamilton is the first open-source Python package for controlling Hamilton liquid-handling robots for biology. SecureDNA is the only DNA screening concept to prioritize anti-proliferation of pathogen genomes, and the first to employ modern cryptography to secure a global screening system that can keep up with anticipated exponential growth of the DNA synthesis market. For each platform developed, a software implementation is provided and exercised in a range of applications, and hardware demonstrators have been produced.
Degree
thesis:*- Name thesis:degree_name
- Master
- Department dc:contributor.department
- Program in Media Arts and Sciences (Massachusetts Institute of Technology)
- Grantor dc:publisher
- Massachusetts Institute of Technology
- Year dc:date.issued
- 2022
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Gretton, Dana
- Advisor dc:contributor.advisor
-
- Esvelt, Kevin M.
Rights
dc:rights- Statement dc:rights
-
- In Copyright - Educational Use Permitted
- Copyright MIT
- Licence dc:rights.uri
Identifiers
dc:identifier.*- Handle dc:identifier.uri
- https://hdl.handle.net/1721.1/151984
- OAI identifier oai:identifier
- oai:dspace.mit.edu:1721.1/151984