Material Handling for Continuous Lyophilization Process

This paper details solutions to two main challenges with a lyophilization machine: load-lock door design for isolating process chambers from the environment and other process chambers operating at different conditions and vacuum seals for complex geometries that are robust to significant temperature variation. The load-lock door design solution detailed in this paper is the wedge door. Using a linear actuation motion and large sealing surface angle with respect to the horizontal, the wedge door requires less space compared to the previous rotary designs, four-bar linkage and simple pivot doors. The wedge door has a length normalized leak rate of [︀formula]︀, and lifetime of 41,992 cycles before service is required which is 9.2 months of operation of the lyophilization machine. In order to seal the complex geometry of the interface between the linear motion system and the load-lock and drying chambers, an injectable vacuum seal was designed. The injectable seal uses Self-leveling Green sealant from Av-DEC injected into a rectangular groove with 2 mm depth and 9.5 mm width and sandblasted sealing surfaces. To fully fill the groove around the linear motion system module, a maximum injection pressure of 45 PSI is required. The injectable seal has a length normalized leak rate of [︀formula]︀.The injectable seal is robust to temperature variation of 10 °C to 25 °C, due to the increased adhesion of sealant to the sealing surfaces due to the increase roughness of the sandblasted surfaces.

Name thesis:degree_name

Master

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Mechanical Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2022

Author dc:creator

• Flores, Ryan Maximiliano

Advisor dc:contributor.advisor

• Slocum, Alexander H.

Statement dc:rights

• In Copyright - Educational Use Permitted
• Copyright MIT

Licence dc:rights.uri

• http://rightsstatements.org/page/InC-EDU/1.0/

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/147415

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/147415