Integrative multi-omics dissection of cancer cell states and susceptibility

Cancer cells are characterized by a broad spectrum of unique genetic, epigenetic and transcriptional states, which are often concomitant with high degrees of plasticity in cell identity. These cell states and the fluidity therein are a major source of resistance to both chemotherapy and targeted therapy. Combinatorial efforts in experimental assays and computational modeling are pivotal for understanding the origins of cancer cell plasticity and exposing cell state-specific vulnerabilities. In this thesis, I will first present my studies on two clinically challenging types of hematopoietic malignancies and discuss key genes that sustain cell identity and survival programs revealed through multi-omics approaches.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Biology

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2021

Author dc:creator

• Liu, Yunpeng(Biologist)Massachusetts Institute of Technology.

Advisor dc:contributor.advisor

• Michael T. Hemann.

• Biology.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/130818

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/130818