LisNRs : a novel class of liposomal contrast agents for molecular MRI

Biological systems depend on numerous molecular messengers that transduce information across large distances. Understanding the spatial and temporal dynamics of molecular signaling networks is crucial for the construction of systems- and organism-level models of biological function. Molecular imaging, a technique that employs chemical probes to relay molecular events into spatially-resolved signal changes, is a promising strategy for studying complex molecular signaling networks in situ. Magnetic resonance imaging (MRI) is a leading noninvasive imaging modality that allows for imaging of large volumes of deep tissue with high spatiotemporal resolution. Paramagnetic molecular sensors enable detection of molecular phenomena with MRI (molecular MRI). The scope of molecular MRI experiments thus far, however, has been limited by the modest sensitivity and signal changes provided by existing probes.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Biological Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2021

Author dc:creator

• Simon, Jacob Cyert.

Advisor dc:contributor.advisor

• Alan Jasanoff.

• Biological Engineering.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/130814

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/130814