Physical consequences of natural and synthetic post-translational modifications

Protein modifications endow diverse chemical and biological functions. Development of new modifications, control over extant, and the appreciation of their consequences promises to unveil the mechanisms of disease, provide avenues of therapeutic development, and provide insight into intricacies of life. As a result, developing, harnessing, and understanding protein modifications has led to profound direct and indirect consequences for biotechnology, the pharmacopeia and academic research. The express purpose of this thesis was to characterize and investigate the consequences of these modifications. This led to investigations into the stereoelectronic effects endemic to the properties of cysteines and disulfide bonds in proteins and provided a rational basis for the function of thioredoxins, thioredoxin-fold enzymes, and other enzymes that bear highly variable reduction potentials.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Chemistry

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2020

Author dc:creator

• Kilgore, Henry R.(Henry Ralph)

Advisor dc:contributor.advisor

• Ronald T. Raines.

• Chemistry.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/130615

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/130615