{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/130613"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/130613","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract","abstract":"Biologics are a class of therapeutic substances composed of large and complex \"macromolecules.\" Examples include vaccines, insulin, monoclonal antibodies, and allergens. However, a practical limitation of these molecules is that they are easily degraded by digestive processes and, as a result, are not generally considered effective for oral dosing. Therefore, these life-saving drugs are typically delivered via intravenous, intramuscular or subcutaneous injection. Oral administration, however, yields some of the highest patient adoption and adherence rates, and is often critical in determining a drug's efficacy. Herein lies the goal of this research: to make it possible to successfully deliver a broad set of biologics by mouth. To that end, needleless delivery, or jetting, has been identified as a promising approach. This work describes mechanistic modeling of jets, an empirical evaluation of jet interaction with gastrointestinal tissues, a millimeter-scale jetting device capable of autonomous drug delivery, and in-vivo studies in which the tested devices elicit substantial drops in blood glucose levels via the delivery of insulin across the gastric mucosa.","abstract_html":"Biologics are a class of therapeutic substances composed of large and complex "macromolecules." Examples include vaccines, insulin, monoclonal antibodies, and allergens. However, a practical limitation of these molecules is that they are easily degraded by digestive processes and, as a result, are not generally considered effective for oral dosing. Therefore, these life-saving drugs are typically delivered via intravenous, intramuscular or subcutaneous injection. Oral administration, however, yields some of the highest patient adoption and adherence rates, and is often critical in determining a drug's efficacy. Herein lies the goal of this research: to make it possible to successfully deliver a broad set of biologics by mouth. To that end, needleless delivery, or jetting, has been identified as a promising approach. This work describes mechanistic modeling of jets, an empirical evaluation of jet interaction with gastrointestinal tissues, a millimeter-scale jetting device capable of autonomous drug delivery, and in-vivo studies in which the tested devices elicit substantial drops in blood glucose levels via the delivery of insulin across the gastric mucosa.","abstract_has_math":false,"creators":["Arrick, Graham(Graham Philip)"],"institution":"Massachusetts Institute of Technology","degree_name":"Master","degree_level":null,"degree_discipline":null,"degree_department":"Massachusetts Institute of Technology. Department of Mechanical Engineering","school":null,"contributors":[],"advisors":["Carlo Giovanni Traverso."],"committee_chairs":[],"committee_members":[],"year":2020,"date_issued":"2020","date_published":"2020","updated_at":"2026-07-22T22:21:19Z","subjects":["Mechanical Engineering."],"languages":["eng"],"rights":["MIT theses may be protected by copyright. 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However, a practical limitation of these molecules is that they are easily degraded by digestive processes and, as a result, are not generally considered effective for oral dosing. Therefore, these life-saving drugs are typically delivered via intravenous, intramuscular or subcutaneous injection. Oral administration, however, yields some of the highest patient adoption and adherence rates, and is often critical in determining a drug's efficacy. Herein lies the goal of this research: to make it possible to successfully deliver a broad set of biologics by mouth. To that end, needleless delivery, or jetting, has been identified as a promising approach. This work describes mechanistic modeling of jets, an empirical evaluation of jet interaction with gastrointestinal tissues, a millimeter-scale jetting device capable of autonomous drug delivery, and in-vivo studies in which the tested devices elicit substantial drops in blood glucose levels via the delivery of insulin across the gastric mucosa."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["S.M."]},{"key":"dc:title","label":"Title","values":["Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract"]}]}],"canonical_facts":{"dc:contributor.advisor":["Carlo Giovanni Traverso."],"dc:contributor.department":["Massachusetts Institute of Technology. Department of Mechanical Engineering","MechE"],"dc:contributor.other":["Massachusetts Institute of Technology. Department of Mechanical Engineering."],"dc:creator":["Arrick, Graham(Graham Philip)"],"dc:date.accessioned":["2021-05-14T16:29:56Z"],"dc:date.available":["2021-05-14T16:29:56Z"],"dc:date.issued":["2020"],"dc:description":["Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020","Cataloged from the official PDF version of thesis.","Includes bibliographical references (pages 59-62)."],"dc:description.abstract":["Biologics are a class of therapeutic substances composed of large and complex \"macromolecules.\" Examples include vaccines, insulin, monoclonal antibodies, and allergens. However, a practical limitation of these molecules is that they are easily degraded by digestive processes and, as a result, are not generally considered effective for oral dosing. Therefore, these life-saving drugs are typically delivered via intravenous, intramuscular or subcutaneous injection. Oral administration, however, yields some of the highest patient adoption and adherence rates, and is often critical in determining a drug's efficacy. Herein lies the goal of this research: to make it possible to successfully deliver a broad set of biologics by mouth. To that end, needleless delivery, or jetting, has been identified as a promising approach. This work describes mechanistic modeling of jets, an empirical evaluation of jet interaction with gastrointestinal tissues, a millimeter-scale jetting device capable of autonomous drug delivery, and in-vivo studies in which the tested devices elicit substantial drops in blood glucose levels via the delivery of insulin across the gastric mucosa."],"dc:description.degree":["S.M."],"dc:identifier.uri":["https://hdl.handle.net/1721.1/130613"],"dc:language.iso":["eng"],"dc:publisher":["Massachusetts Institute of Technology"],"dc:rights":["MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided."],"dc:rights.uri":["http://dspace.mit.edu/handle/1721.1/7582"],"dc:subject":["Mechanical Engineering."],"dc:title":["Delivery of macromolecule therapeutics via jetting in the gastrointestinal tract"],"dc:type":["Thesis"],"thesis:degree_name":["Master"]},"updated_at":"2026-07-22T22:21:19Z"}