Exploring cancer metabolism through isotopic tracing and metabolic flux analysis

Cancer is the second leading cause of death following heart diseases in the U.S. During the past two decades, cancer metabolism has emerged as an indispensable part of contemporary cancer research. Various types of metabolic alterations in cancer cells have been documented, prompting extensive investigation of the link between reprogrammed cell signaling pathways and rewired cellular metabolism. In addition, drug targeting of rewired metabolic pathways has been demonstrated to be a promising cancer treatment strategy. Despite this progress, a fundamental question remains unanswered: whether there is a difference in the metabolism of cancerous, fast growing cells and normal proliferative cells. This deficiency has hindered our understanding of cancer metabolism and the efforts to develop effective cancer therapies targeting metabolism with reduced side effects.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Chemical Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2020

Author dc:creator

• Dong, Wentao,Ph. D.Massachusetts Institute of Technology.

Advisor dc:contributor.advisor

• Gregory Stephanopoulos.

• Chemical Engineering.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/130611

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/130611