Dewdrops on the genome : regulation of gene expression by biomolecular phase separation

Human development and physiology depend on the coordinated function of thousands of cell types - for example, neurons, immune cells, and skin cells. Each cell-type contains an identical copy of the genetic material yet performs specialized and diverse functions, in large part, due to the selective expression of particular coding DNA-elements (genes) into RNA. Mutations or dysregulation in control of gene expression underlie many diseased states, including cancer and neurodegenerative disorders. Non-coding DNA elements called enhancers orchestrate the complex biochemical pathways that lead to precise activation of cell-type specific genes. Decades of advances in molecular biology have identified many of the key proteins and their interactions in these pathways.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Chemical Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2020

Author dc:creator

• Shrinivas, Krishna,Ph. D.Massachusetts Institute of Technology.

Advisor dc:contributor.advisor

• Arup K. Chakraborty.

• Chemical Engineering.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/130193

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/130193