Transcriptome-wide organization of subcellular microenvironments revealed by ATLAS-Seq

Subcellular localization of RNAs is a ubiquitous and evolutionarily conserved process that provides an additional layer of transcriptome organization promoting coordinated control of gene expression in both space and time. It has been shown to contribute to processes ranging from cell fate determination and embryonic patterning to local translation and directed cell movement. Elegant efforts focused on a small handful of RNAs have established RNA localization to play key roles in cell function - yet recent studies suggest that specific localization patterns are the rule, not the exception, across the transcriptome. We still lack global maps and organizing principles for how RNAs are localized in cells and tissues.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Biology

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2020

Author dc:creator

• Adekunle, Danielle(Danielle Aduke)

Advisor dc:contributor.advisor

• Eric T. Wang and Phillip A. Sharp.

• Biology.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/130189

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/130189