Engineering micro-perfusable scaffolds for MesoPhysiological Systems using projection Micro-StereoLithography

MicroPhysiological Systems (MPS) are in vitro models that capture the complexity of human organs at miniature scale by recreating the native microenvironment of resident cells. These systems offer promising alternatives to in vivo animal models for the development of new drugs, disease modeling and biological research. The organs in the human body are continuously perfused via a dense network of blood vessels delivering oxygen, nutrients and biomolecules locally while clearing waste materials produced by the tissue. As a result, MPS that incorporate microperfusion in a three-dimensional format have been a major focal point in the community driving major efforts towards in vitro vascularization methods. A major obstacle to the development of these MPS was the micrometric scale of the human cells forming the building block of any biological system.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Mechanical Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2020

Author dc:creator

• Sphabmixay, Pierre.

Advisor dc:contributor.advisor

• Linda G. Griffith.

• Mechanical Engineering.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/129115

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/129115