A histological and immunological response study of an implantable microcapsule drug delivery device for the treatment of glioblastoma

Glioblastoma Multiform (GBM) and the more prevalent metastatic brain tumor are some of the most deadly forms of cancer, accounting for the death of nearly 14,000 individuals yearly. Previous treatment options for brain cancers include tumor resection, radiation, and chemo therapy but such options provide limited success in prolonging patients' life. Most patients experience tumor recurrence near the resected areas within a few months and are ineligible for additional rounds of chemotherapy due to systemic toxicity associated with many chemotherapeutic drugs. Advances in implantable drug delivery devices look promising, but can suffer from the possibility of biofouling, or loss of function due to a patient's own immune response. An implantable microcapsule device, designed to deliver locally chemotherapeutics in the brain, was developed by Alex Scott and Yoda Patta in the Cima Lab at the MIT Koch Institute for Integrative Cancer Research.

Name thesis:degree_name

Bachelor

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Materials Science and Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2012

Author dc:creator

• Van Schaik, Graham(Graham W.)

Advisor dc:contributor.advisor

• Michael J. Cima.

• Materials Science and Engineering.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/127718

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/127718