The spatial organization of the microtubule cytoskeleton and cell divisions promotes tissue morphogenesis

During embryonic development, epithelial tissues grow and become sculpted into complex shapes through highly coordinated cell behaviors, such as cell shape change and cell division. Both processes involve contractile forces generated from distinctly organized actomyosin networks. How cells coordinate their behaviors and how different cell behaviors interact to affect tissue shape remain long-standing questions in developmental biology. One way that a single cell behavior can be coordinated, such as during collective cell shape changes (apical constriction), is through the attachment of actomyosin networks in each cell to adherens junctions, allowing contractile forces to be integrated across the epithelium. However, how actomyosin connections to junctions are maintained during morphogenesis is poorly understood.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Biology

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2020

Author dc:creator

• Ko, Clint S.

Advisor dc:contributor.advisor

• Adam C. Martin.

• Biology.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/127696

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/127696