Collective cellular behavior on curved surface

Organ surface is tiled by a confluent monolayer of epithelial or endothelial cells, thus providing a physical barrier to the external environment. Cells on these confluent layers often remain static and non-migratory. However, they can also undergo active structural rearrangements during basic physiological processes such as embryonic development, tissue repair as wells as tumor metastasis. While most of existing research of collective cellular behavior are on flat two dimensional (2D) space, most native biological systems however are intrinsically curved, including mature respiratory bronchioles, alveoli, and embryonic tissues. There are fundamental reasons to suspect that such curved geometries will alter collective cellular dynamics in a nontrivial manner. In particular, as the radius of curvature decreases, it inevitably affects packing of objects on the surface.

Name thesis:degree_name

Master

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Mechanical Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2020

Author dc:creator

• Tang, Wenhui,S.M.Massachusetts Institute of Technology.

Advisor dc:contributor.advisor

• Ming Guo.

• Mechanical Engineering.

Statement dc:rights

• MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/127112

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/127112