{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/124116"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/124116","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Mechanistic modeling of bacterial nutrient uptake strategies","abstract":"Bacteria have developed a variety of strategies to nd and consume the substrates necessary for both the cell's energy-consuming processes and for the additional biomass needed to replicate. A greater understanding of the diversity and regulation of these strategies can provide us with a number of insights relevant for a variety of applications, from predicting bacterial population dynamics and thus carbon-cycling rates in the ocean to bio-engineering bacteria into microscale robots. Here I use toy, mechanistic models of single-cell metabolism that allow me to quantify the costs and benefits of various nutrient uptake strategies. I find that: (i) a sensing-uptake trade-off governs E. coli's regulation of maltose uptake and chemotaxis to maltose; (ii) a rate-affinity trade-off in nutrient transport systems governs the speciation of marine oligotrophic and copiotrophic heterotrophs; and (iii) an exploration-conservation trade-off governs the prevalence of motility in the marine microbial world. This work thus provides new understanding of how both phenotypic diversity and cellular regulation are governed by trade-offs for maximizing growth rate in dierent environments.","abstract_html":"Bacteria have developed a variety of strategies to nd and consume the substrates necessary for both the cell's energy-consuming processes and for the additional biomass needed to replicate. A greater understanding of the diversity and regulation of these strategies can provide us with a number of insights relevant for a variety of applications, from predicting bacterial population dynamics and thus carbon-cycling rates in the ocean to bio-engineering bacteria into microscale robots. Here I use toy, mechanistic models of single-cell metabolism that allow me to quantify the costs and benefits of various nutrient uptake strategies. I find that: (i) a sensing-uptake trade-off governs E. coli's regulation of maltose uptake and chemotaxis to maltose; (ii) a rate-affinity trade-off in nutrient transport systems governs the speciation of marine oligotrophic and copiotrophic heterotrophs; and (iii) an exploration-conservation trade-off governs the prevalence of motility in the marine microbial world. This work thus provides new understanding of how both phenotypic diversity and cellular regulation are governed by trade-offs for maximizing growth rate in dierent environments.","abstract_has_math":false,"creators":["Norris, Noele Rosalie."],"institution":"Massachusetts Institute of Technology","degree_name":"Doctoral","degree_level":null,"degree_discipline":null,"degree_department":"Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science","school":null,"contributors":[],"advisors":["Emilio Frazzoli and Roman Stocker."],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019","date_published":"2019","updated_at":"2026-07-22T22:20:47Z","subjects":["Electrical Engineering and Computer Science."],"languages":["eng"],"rights":["MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."],"rights_urls":["http://dspace.mit.edu/handle/1721.1/7582"],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/1721.1/124116","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Emilio Frazzoli and Roman Stocker."]},{"key":"dc:contributor.department","label":"Department","values":["Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science","EECS"]},{"key":"dc:contributor.other","label":"Dc Contributor Other","values":["Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science."]},{"key":"dc:creator","label":"Author","values":["Norris, Noele Rosalie."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2020-03-09T18:58:42Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2020-03-09T18:58:42Z"]},{"key":"dc:date.issued","label":"Date","values":["2019"]},{"key":"dc:publisher","label":"Institution","values":["Massachusetts Institute of Technology"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctoral"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Electrical Engineering and Computer Science."]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://dspace.mit.edu/handle/1721.1/7582"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/1721.1/124116"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.","Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2019","Cataloged from student-submitted PDF version of thesis.","Includes bibliographical references (pages 155-172)."]},{"key":"dc:description.abstract","label":"Abstract","values":["Bacteria have developed a variety of strategies to nd and consume the substrates necessary for both the cell's energy-consuming processes and for the additional biomass needed to replicate. A greater understanding of the diversity and regulation of these strategies can provide us with a number of insights relevant for a variety of applications, from predicting bacterial population dynamics and thus carbon-cycling rates in the ocean to bio-engineering bacteria into microscale robots. Here I use toy, mechanistic models of single-cell metabolism that allow me to quantify the costs and benefits of various nutrient uptake strategies. I find that: (i) a sensing-uptake trade-off governs E. coli's regulation of maltose uptake and chemotaxis to maltose; (ii) a rate-affinity trade-off in nutrient transport systems governs the speciation of marine oligotrophic and copiotrophic heterotrophs; and (iii) an exploration-conservation trade-off governs the prevalence of motility in the marine microbial world. This work thus provides new understanding of how both phenotypic diversity and cellular regulation are governed by trade-offs for maximizing growth rate in dierent environments."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Ph. D."]},{"key":"dc:title","label":"Title","values":["Mechanistic modeling of bacterial nutrient uptake strategies"]}]}],"canonical_facts":{"dc:contributor.advisor":["Emilio Frazzoli and Roman Stocker."],"dc:contributor.department":["Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science","EECS"],"dc:contributor.other":["Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science."],"dc:creator":["Norris, Noele Rosalie."],"dc:date.accessioned":["2020-03-09T18:58:42Z"],"dc:date.available":["2020-03-09T18:58:42Z"],"dc:date.issued":["2019"],"dc:description":["This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.","Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2019","Cataloged from student-submitted PDF version of thesis.","Includes bibliographical references (pages 155-172)."],"dc:description.abstract":["Bacteria have developed a variety of strategies to nd and consume the substrates necessary for both the cell's energy-consuming processes and for the additional biomass needed to replicate. A greater understanding of the diversity and regulation of these strategies can provide us with a number of insights relevant for a variety of applications, from predicting bacterial population dynamics and thus carbon-cycling rates in the ocean to bio-engineering bacteria into microscale robots. Here I use toy, mechanistic models of single-cell metabolism that allow me to quantify the costs and benefits of various nutrient uptake strategies. I find that: (i) a sensing-uptake trade-off governs E. coli's regulation of maltose uptake and chemotaxis to maltose; (ii) a rate-affinity trade-off in nutrient transport systems governs the speciation of marine oligotrophic and copiotrophic heterotrophs; and (iii) an exploration-conservation trade-off governs the prevalence of motility in the marine microbial world. This work thus provides new understanding of how both phenotypic diversity and cellular regulation are governed by trade-offs for maximizing growth rate in dierent environments."],"dc:description.degree":["Ph. D."],"dc:identifier.uri":["https://hdl.handle.net/1721.1/124116"],"dc:language.iso":["eng"],"dc:publisher":["Massachusetts Institute of Technology"],"dc:rights":["MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."],"dc:rights.uri":["http://dspace.mit.edu/handle/1721.1/7582"],"dc:subject":["Electrical Engineering and Computer Science."],"dc:title":["Mechanistic modeling of bacterial nutrient uptake strategies"],"dc:type":["Thesis"],"thesis:degree_name":["Doctoral"]},"updated_at":"2026-07-22T22:20:47Z"}