Portable magnetic resonance sensors and methods for noninvasive disease diagnostics

Many diseases manifest as a shift in fluids between distinct tissue fluid compartments. For example, fluid depletion and fluid overload lead to a deficit or accumulation of fluids within the intramuscular interstitial space. A direct measurement of these fluid shifts could serve as a highly specific diagnostic or prognostic tool to improve clinical management of these disorders. Proton magnetic resonance is exquisitely sensitive to the local physical and chemical environment of water molecules within the body. Therefore, we hypothesized that localized magnetic resonance (MR) measurements could interrogate local tissue fluid distributions and assess systemic fluid volume status. This thesis explored the potential for a portable MR sensor to characterize shifts in tissue fluid distribution and identify the onset and progression of fluid volume status disorders.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2019

Author dc:creator

• Bashyam, Ashvin(Ashvin Reddy)

Advisor dc:contributor.advisor

• Michael J. Cima.

• Electrical Engineering and Computer Science.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/124112

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/124112