Continuous processing of multiphase reactions for pharmaceutical applications

With current needs to expedite new drug development, reduce cost and increase availability of existing drugs, and improve stability and safety of pharmaceutical manufacturing, the continuous flow synthesis has appeared as an attractive alternative to the conventional batch processes. Numerous technologies have emerged to facilitate the development of continuous flow chemistry, and the benefits of flow chemistry have been successfully demonstrated for many chemistries that would otherwise be challenging in conventional batch process because of demanding process conditions, hazardous intermediates, and limitations in mass and heat transfer. However, in contrast to single-phase reaction, transformation of multiphase reactions from batch to continuous flow still remains cumbersome due to complicated multiphase hydrodynamics, mass transfer, interfacial reaction kinetics, and potential clogging issues of solids.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Chemical Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2019

Author dc:creator

• Mo, Yiming,Ph. D.Massachusetts Institute of Technology.

Advisor dc:contributor.advisor

• Klavs F. Jensen.

• Chemical Engineering.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/124041

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/124041