Implementation of automated visual inspection machines in biopharmaceutical industry

Currently, manual visual inspection is the gold standard for the required visual inspection of particulate matter in parenteral medicines. Automated visual inspection machines offer an opportunity for Amgen to improve efficiency, rate and consistency, while reducing its equipment footprint. However, the implementation of automated visual inspection poses challenges that need to be resolved. This thesis identified and developed solutions to three execution pain points: (1) low detection rates of dense particles in products; (2) misuse of automated inspection machines for product impact testing; and (3) ambiguous understanding of cost drivers when selecting an inspection method. The pain points mentioned above were addressed separately. First, experiments with modified plunger surfaces were conducted to determine their effectiveness at agitating dense particles into solution where the particles could then be easily detected.

Name thesis:degree_name

Master

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Mechanical Engineering

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2019

Author dc:creator

• Nyovanie, Prosper M.(Prosper Munaishe)

Advisor dc:contributor.advisor

• Sang-Gook Kim.

• Mechanical Engineering.
• Sloan School of Management.
• Leaders for Global Operations Program.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/123640

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/123640