{"id":{"repo_id":"mit","oai_identifier":"oai:dspace.mit.edu:1721.1/122536"},"canonical_url":"https://search.dev.ndltd.org/etd/mit/oai:dspace.mit.edu:1721.1/122536","repository":{"repo_id":"mit","name":"MIT","base_url":"https://dspace.mit.edu/oai/request"},"display":{"title":"Self-assembly of lead-halide-perovskite laser particles","abstract":"As profiling the molecular states of cellular subpopulations has become increasingly important to understand complex systems in biology and medicine, considerable efforts are being made to develop multiplexed techniques. While current fluorescent probes play indispensable roles, their broad emission spectra (about 30-100 nm) limit multiplexing capability. Recently, optical probes emitting narrowband laser spectra (about 0.1-1 nm), called 'laser particles', has drawn attention. Semiconductor microdisk lasers fabricated by top-down lithography have shown potential for massive multiplexing of thousands to millions of samples. In the thesis, I investigated lead halide perovskites (LHP) as a novel material for scalable production of laser particles in a lab flask. I discovered a sonochemical method to produce a large quantity (10 billions/L) of high-quality LHP micro- and sub-micron particles in a polar solvent within minutes. This method enabled me to coat the surface of individual CsPbBr3 laser particles using poly-catecholamine and thereby to improve optical properties and material stability against moisture. With CsPbBr3 microparticles coated with nano-scatterers, I realized disordered lasing based on Anderson localization. In addition, by incorporating plasmonic materials, I demonstrated plasmonic-lasing particles as small as 580 nm. This work paves the way for highly multiplexable laser particles for biomedical applications.","abstract_html":"As profiling the molecular states of cellular subpopulations has become increasingly important to understand complex systems in biology and medicine, considerable efforts are being made to develop multiplexed techniques. While current fluorescent probes play indispensable roles, their broad emission spectra (about 30-100 nm) limit multiplexing capability. Recently, optical probes emitting narrowband laser spectra (about 0.1-1 nm), called 'laser particles', has drawn attention. Semiconductor microdisk lasers fabricated by top-down lithography have shown potential for massive multiplexing of thousands to millions of samples. In the thesis, I investigated lead halide perovskites (LHP) as a novel material for scalable production of laser particles in a lab flask. I discovered a sonochemical method to produce a large quantity (10 billions/L) of high-quality LHP micro- and sub-micron particles in a polar solvent within minutes. This method enabled me to coat the surface of individual CsPbBr3 laser particles using poly-catecholamine and thereby to improve optical properties and material stability against moisture. With CsPbBr3 microparticles coated with nano-scatterers, I realized disordered lasing based on Anderson localization. In addition, by incorporating plasmonic materials, I demonstrated plasmonic-lasing particles as small as 580 nm. This work paves the way for highly multiplexable laser particles for biomedical applications.","abstract_has_math":false,"creators":["Cho, Sangyeon,Ph. D.Massachusetts Institute of Technology."],"institution":"Massachusetts Institute of Technology","degree_name":"Doctoral","degree_level":null,"degree_discipline":null,"degree_department":"Harvard--MIT Program in Health Sciences and Technology","school":null,"contributors":[],"advisors":["Seok Hyun (Andy) Yun."],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019","date_published":"2019","updated_at":"2026-07-22T22:21:45Z","subjects":["Harvard--MIT Program in Health Sciences and Technology."],"languages":["eng"],"rights":["MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."],"rights_urls":["http://dspace.mit.edu/handle/1721.1/7582"],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/1721.1/122536","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Seok Hyun (Andy) Yun."]},{"key":"dc:contributor.department","label":"Department","values":["Harvard--MIT Program in Health Sciences and Technology","HST"]},{"key":"dc:contributor.other","label":"Dc Contributor Other","values":["Harvard--MIT Program in Health Sciences and Technology."]},{"key":"dc:creator","label":"Author","values":["Cho, Sangyeon,Ph. 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They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission."]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://dspace.mit.edu/handle/1721.1/7582"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/1721.1/122536"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Thesis: Ph. D., Harvard-MIT Program in Health Sciences and Technology, 2019","Cataloged from student-submitted PDF version of thesis.","Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["As profiling the molecular states of cellular subpopulations has become increasingly important to understand complex systems in biology and medicine, considerable efforts are being made to develop multiplexed techniques. While current fluorescent probes play indispensable roles, their broad emission spectra (about 30-100 nm) limit multiplexing capability. Recently, optical probes emitting narrowband laser spectra (about 0.1-1 nm), called 'laser particles', has drawn attention. Semiconductor microdisk lasers fabricated by top-down lithography have shown potential for massive multiplexing of thousands to millions of samples. In the thesis, I investigated lead halide perovskites (LHP) as a novel material for scalable production of laser particles in a lab flask. I discovered a sonochemical method to produce a large quantity (10 billions/L) of high-quality LHP micro- and sub-micron particles in a polar solvent within minutes. This method enabled me to coat the surface of individual CsPbBr3 laser particles using poly-catecholamine and thereby to improve optical properties and material stability against moisture. With CsPbBr3 microparticles coated with nano-scatterers, I realized disordered lasing based on Anderson localization. In addition, by incorporating plasmonic materials, I demonstrated plasmonic-lasing particles as small as 580 nm. This work paves the way for highly multiplexable laser particles for biomedical applications."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Ph. D."]},{"key":"dc:title","label":"Title","values":["Self-assembly of lead-halide-perovskite laser particles"]}]}],"canonical_facts":{"dc:contributor.advisor":["Seok Hyun (Andy) Yun."],"dc:contributor.department":["Harvard--MIT Program in Health Sciences and Technology","HST"],"dc:contributor.other":["Harvard--MIT Program in Health Sciences and Technology."],"dc:creator":["Cho, Sangyeon,Ph. D.Massachusetts Institute of Technology."],"dc:date.accessioned":["2019-10-11T22:10:49Z"],"dc:date.available":["2019-10-11T22:10:49Z"],"dc:date.issued":["2019"],"dc:description":["Thesis: Ph. 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I discovered a sonochemical method to produce a large quantity (10 billions/L) of high-quality LHP micro- and sub-micron particles in a polar solvent within minutes. This method enabled me to coat the surface of individual CsPbBr3 laser particles using poly-catecholamine and thereby to improve optical properties and material stability against moisture. With CsPbBr3 microparticles coated with nano-scatterers, I realized disordered lasing based on Anderson localization. In addition, by incorporating plasmonic materials, I demonstrated plasmonic-lasing particles as small as 580 nm. This work paves the way for highly multiplexable laser particles for biomedical applications."],"dc:description.degree":["Ph. D."],"dc:identifier.uri":["https://hdl.handle.net/1721.1/122536"],"dc:language.iso":["eng"],"dc:publisher":["Massachusetts Institute of Technology"],"dc:rights":["MIT theses are protected by copyright. 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