Portfolio optimization in early drug R&D : a deeper dive into underlying dynamics of early research in pharmaceutical/biotech sector

Pharmaceutical R&D involves significant uncertainty, including high attrition rate and long time for a project to progress from a target identification phase to commercial launch. Despite this uncertainty, senior leaders must make decisions about R&D portfolio, the impact of which may not be observable for many years. Hence the purpose of this thesis is to understand the current state of Pharmaceutical R&D portfolio management and identify the gaps in R&D portfolio management research. The literature survey revealed that though there are many qualitative and quantitative approaches for the portfolio management of projects in the development phase (i.e. from pre-clinical to phase 3.), the topic of portfolio management in the drug discovery phase (i.e. target validation to lead optimization) have not been well covered in the literature. Hence the problem statement of this thesis is to develop a portfolio management approach for drug discovery.

Name thesis:degree_name

Master

Department dc:contributor.department

Massachusetts Institute of Technology. Engineering and Management Program

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2019

Author dc:creator

• Badwe, Ravi.

Advisor dc:contributor.advisor

• Bryan R . Moser.

• Engineering and Management Program.
• System Design and Management Program.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/122442

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/122442