Genetic regulation of cell extrusion in caenorhabditis elegans

Programmed elimination of cells occurs during animal development and homeostasis to maintain appropriate cell numbers. One evolutionarily conserved method by which organisms eliminate cells in a programmed manner is by cell-autonomous activation of the caspase-mediated apoptosis pathway, which produces a corpse that is engulfed and degraded by phagocytic cells. Cell elimination can also occur by a different method, called cell extrusion, in which the cell to be eliminated is squeezed out from a layer of cells, such as an epithelium. Cell extrusion is also an evolutionarily conserved form of cell elimination and has been observed in organisms ranging from Drosophila to mammals. It is the primary method of cell elimination in mammalian epithelial tissues, such as the small intestinal epithelium. A specific set of cells is eliminated by cell extrusion by caspase-deficient C. elegans embryos.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Massachusetts Institute of Technology. Department of Biology

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2019

Author dc:creator

• Dwivedi, Vivek Kumar.

Advisor dc:contributor.advisor

• H. Robert Horvitz.

• Biology.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/122207

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/122207